منابع مشابه
The Expanding Universe of Prion Diseases
Prions cause fatal and transmissible neurodegenerative disease. These etiological infectious agents are formed in greater part from a misfolded cell-surface protein called PrP(C). Several mammalian species are affected by the diseases, and in the case of "mad cow disease" (BSE) the agent has a tropism for humans, with negative consequences for agribusiness and public health. Unfortunately, the ...
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Escherichia coli DNA polymerase I (pol I), discovered by Arthur Kornberg and colleagues in 1956. Thirteen years later, Paula de Lucia and John Cairns, at Stony Brook, New York, isolated an E. coli mutant, polA (its designation being a play on de Lucia’s first name, as proposed to Cairns by Julian Gross) that seemed to have less than 1% of the normal pol I activity. From this strain, a new DNA-p...
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Wewanttofindthecosmologicalconstantinfluenceoncosmicmicrowavebackground(CMB)temperatureduetomovinglinearcosmicstrings.Usingthespace-timemetricofalinearcosmicstringinanacceleratedexpandinguniverse,theGott-Kaiser Stebbins(GKS)effect,asanimportantmechanisminproducingtemperaturediscontinuityinthe(CMB),isconsidered;then,itsmodificationduetotheeffectofthecosmologicalconstantiscalculated.Theresultshowsthat...
متن کاملExpanding the prion disease repertoire.
In 1982, Stanley Prusiner proposed that the infectious agent of transmissible spongiform encephalopathies (TSEs), a group of relatively rare neurodegenerative disorders that includes Creutzfeldt–Jakob disease and scrapie, lacks replicating nucleic acids and instead is composed primarily of a misfolded conformation of the prion protein, which he termed PrP (1). Originally, the “prion” hypothesis...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2006
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.0020026